Bone profile A is a preventive health checkup package by Thyrocare. It includes 8 test parameters. Bone profile is to assess the bone diseases such as osteoporosis, parathyroid disorders, osteomalacia, osteopenia, Paget’s disease, etc. this test is ordered when a person experience some symptoms such as joint pain, deformed bones, tiredness, weakness, muscle weakness, vomiting, constipation, nausea, polyuria, etc. it is also used to check the effect of the treatment.
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Bone Profile A includes 8 Test Parameters.
1. 25-OH Vitamin D Total.
2. Intact Parathyroid Hormone.
5. Alkaline Phosphatase.
6. Serum Zinc.
7. Vitamin B12.
1. 25-OH Vitamin D Total:
This test check for any vitamin D deficiency in the body. It is also known as calcidiol. Vitamin D is required for the growth of bones and teeth. There are 2 forms of Vitamin D, i.e., 25-OH vitamin D and 1-25 dihydroxy vitamin D. vitamin D can be obtained by endogenous and exogenous. Endogenous is produced when the skin comes to the sunlight. Exogenous sources come through the foods we eat and supplements. Vitamin D is used to regulate phosphorus, calcium, and magnesium. Vitamin D deficiency leads to soft bones, malformed, rickets, osteomalacia, etc. sources of vitamin D are bread, eggs, cereals, fortified milk, etc. the average level of vitamin D is 20-50 ng/dl.
2. Intact Parathyroid Hormone:
Intact parathyroid hormone test is performed to evaluate the parathyroid function. It is also used to detect the cause of calcium imbalances. The main purpose of parathyroid hormone is to maintain the level of calcium in the blood. Low level of calcium and parathyroid hormone leads to hypercalcemia or hypocalcemia. Use of drugs can elevate the parathyroid hormone level. Some of these drugs are lithium, rifampin, steroids, anticonvulsants etc.
Intact Parathyroid hormone test is ordered when the calcium level is abnormal.
Symptoms of an increase in calcium level:
4. Abdominal pain.
Symptoms of a decrease in calcium level:
1. Muscle cramps.
2. Abdominal pain.
3. Tingling fingers and toes.
Calcium test is used to determine the total amount of calcium in the blood. Usually, most of the calcium is stored in the bones. Calcium is important for the proper functioning of the heart, nerve, and muscles. Calcium helps the body in blood clotting. The main objective of this test is to monitor and diagnose conditions regarding heart, bones, nerves, kidneys, and teeth. It is also suggested to those people who have symptoms of malabsorption, overactive thyroid, and parathyroid disorder.
Calcium test can be used to diagnose:
1. Kidney stones.
2. Bone disease.
3. Neurologic disorder.
Calcium test is suggested when a person has:
1. Kidney disease.
2. Thyroid disease.
4. Malabsorption cancer.
Symptoms of high calcium level:
3. Loss of appetite.
6. Increased thirst.
This test is used to evaluate the level of phosphate in the blood. It is a mineral which combines with other substances to form phosphate compounds. Phosphorus is important for nerve function, bone growth, and energy production. Phosphorus can be obtained by the foods, and the digestive tract absorbs it. Usually, the phosphorus test is ordered with calcium, parathyroid hormone, and Vitamin D tests to know the cause of phosphorus and calcium imbalance.
Low level of phosphorus indicates:
3. Severe burns.
4. Chronic antacid use.
5. Rickets and osteomalacia.
6. Severe burns.
7. Diabetic ketoacidosis.
High level of phosphorus indicates:
1. Liver disease.
2. Kidney disease.
3. Increased dietary intake.
4. Diabetic ketoacidosis.
5. Alkaline phosphatase:
Alkaline phosphatase is an enzyme. Enzymes are a protein which acts as an intermediate in a chemical reaction. This test is used to determine the level of alkaline phosphatase in the blood. It is found in the liver, bones, kidneys, digestive system. The higher level of alkaline phosphatase indicates bone and liver disease.
Symptoms of liver disease:
1. Weight loss.
4. Frequent itching.
Symptoms of bone disorder:
1. Pain in the joints and bones.
2. Increased frequency of bone fractures.
3. Enlarged and abnormally shaped bones.
6. Serum Zinc:
Serum zinc test is used to measure the amount of zinc in the blood. It measures the zinc level in plasma and urine. It is important for protein synthesis, enzyme function, etc. it can be found in many foods such as meat, fish, dairy products, etc. zinc deficiency can cause hair loss, impaired immune function, poor wound healing.
7. Vitamin B12:
It is used to know the amount of vitamin B12 in the body. It helps the body to produce red blood cells and DNA. The primary source of Vitamin B12 are eggs, fish, meat, poultry, etc.
Symptoms of Vitamin B12 deficiency:
1. Pale skin.
2. Smooth tongue.
3. Weakness, tiredness.
4. Vision loss.
5. Mental problems like depression, behavioural changes, memory loss, etc.
6. Loss of appetite.
7. Shortness of breath.
It is used to evaluate the level of magnesium in the blood. It is also used to detect the cause of magnesium, potassium, calcium abnormal levels.
Low level of magnesium is seen with:
1. Uncontrolled diabetes.
3. Severe burns.
5. Digestive disorders.
6. Prolonged diarrhoea.