- Extractable Nuclear Antigen (ENA) Panel, Quantitative (7)
- Centromeres
- JO-1
- Scl-70
- Smith (Sm)
- SS-A (RO)
- SS-B (La)
- U1RNP
The ENA Profile, also known as the Anti-Nuclear Antibodies (ANA) Profile, Quantitative, is a comprehensive set of laboratory tests that measures the levels of specific autoantibodies against various extractable nuclear antigens. These antibodies are directed against components of the cell nucleus and are associated with different autoimmune diseases. The ENA Profile, Quantitative, includes the following specific antibodies:
- Centromeres – Antibodies against centromeric proteins. These are associated with certain autoimmune conditions, including CREST syndrome, a variant of systemic sclerosis.
- JO-1 (Histidyl tRNA synthetase) – Antibodies against the JO-1 antigen. These are associated with autoimmune diseases like polymyositis and dermatomyositis.
- Scl-70 (Topoisomerase I) – Antibodies against the Scl-70 antigen. These are specifically associated with diffuse systemic sclerosis.
- Smith (Sm) – Antibodies against the Smith antigen. These are highly specific for systemic lupus erythematosus (SLE).
- SS-A (Ro) – Antibodies against the SS-A (Ro) antigen. These are associated with Sjögren’s syndrome and SLE.
- SS-B (La) – Antibodies against the SS-B (La) antigen. These are also associated with Sjögren’s syndrome and SLE.
- U1RNP (U1 Ribonucleoprotein) – Antibodies against the U1 ribonucleoprotein. These are associated with mixed connective tissue disease (MCTD).
The ENA Profile, Quantitative, is an important tool for diagnosing and monitoring autoimmune diseases. Elevated levels of these autoantibodies can provide valuable information for healthcare professionals in identifying specific autoimmune conditions and guiding appropriate treatment plans.