- JAK2 V617F Mutation Detection (1)
- JAK2 V617F Mutation Detection
The JAK2 V617 Reflex Panel is a specific genetic test that focuses on detecting the JAK2 V617F mutation. This mutation is associated with certain blood disorders, particularly myeloproliferative neoplasms (MPNs) such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).
The JAK2 V617F mutation leads to the abnormal activation of the JAK2 protein, which plays a crucial role in regulating blood cell production. The mutation is found in a significant proportion of individuals with MPNs, and its detection is important for diagnosing and monitoring these disorders.
The JAK2 V617 Reflex Panel includes tests that specifically target the JAK2 V617F mutation. If the initial test detects the mutation, further reflex testing may be done to assess the presence of other mutations or specific genetic alterations associated with MPNs.
This test is typically ordered for individuals who present with symptoms suggestive of MPNs, such as unexplained high red blood cell or platelet counts, and for those with a suspected family history of these conditions.