Myeloproliferative Neoplasm (MPN) Panel By PCR

1. Calreticulin (CALR) Mutation (1)
   1. Calreticulin (CALR) Mutation
2. JAK2 V617F Mutation Detection (1)
   1. JAK2 V617F Mutation Detection
3. Myeloproliferative Leukemia (MPL) Mutation Detection (1)
   1. Myeloproliferative Leukemia (MPL) Mutation Detection

The Myeloproliferative Neoplasm (MPN) Panel By PCR is a specialized genetic test used to detect specific mutations associated with myeloproliferative neoplasms. These neoplasms are a group of rare blood disorders characterized by the overproduction of blood cells in the bone marrow.

The panel includes the following tests:

1. Calreticulin (CALR) Mutation Detection: The CALR gene mutation is a common genetic abnormality found in certain types of MPNs, particularly essential thrombocythemia (ET) and primary myelofibrosis (PMF). This test identifies the presence of CALR mutations.

2. JAK2 V617F Mutation Detection: The JAK2 V617F mutation is another common genetic alteration found in MPNs, including polycythemia vera (PV), ET, and PMF. This test determines the presence of JAK2 V617F mutation.

3. Myeloproliferative Leukemia (MPL) Mutation Detection: MPL mutations are less common but can be present in some cases of MPNs. This test identifies the presence of MPL mutations.

By analyzing the DNA from a patient’s blood sample, these tests can help in the diagnosis and subclassification of MPNs. Detecting these specific mutations can be crucial in confirming the diagnosis, guiding treatment decisions, and predicting the disease course and prognosis.

It’s important to note that the interpretation of these test results should be done by a qualified medical professional, such as a hematologist or oncologist, who specializes in the management of myeloproliferative neoplasms. The test results, along with other clinical and laboratory findings, will guide the appropriate management and treatment plan for the patient.